Abstract Schistosoma is a waterborne infection that can pose a serious health consequence for all living things in general and humans in particular. High S. mansoni infection of rodents was recorded among those found in human sewage contamination around home ranges, in high local snail abundance areas and a high movement pattern of rodents between transmission sites. The schistosome life cycle occurs in 2 hosts: snails and mammals. Either asexual or sexual reproduction occurs, depending on the type of host. Schistosomiasis is caused by infection with blood flukes of the genus Schistosoma. parasites can induce an immunosuppressive environment to evade the immune system. This also benefits the host, as a reduced inflammatory response limits tissue damage. The most well-known S. mansoni proteases are cysteine and aspartic proteases, as well as the serine proteases (SP)s. The Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints, resulting in both cartilage destruction and bone erosion. The CIA autoimmune mouse model is widely used to study RA. Infection of mice with either S. mansoni or S. japonicum prior to collagen immunization reduced the severity of CIA. Autoclaved antigen, derived from S. mansoni cercariae (ASMA), has been tested for a potential protective effect on adjuvant arthritis (CFA-induced AA) induced in rats by subcutaneous and intradermal injections of complete Freund’s adjuvant into the paw and tail, respectively.