Antibiograms are reports summarising the rates of bacterial antibiotic susceptibility inside a specific institution over the course of a calendar year. This study aims to ascertain the prevalence and types of pathogens as well as their antibiotic susceptibility and resistance at surgical and emergency intensive care units (ICUs) at Zagazig University Hospitals. Methods: A one-year retrospective analytical study was conducted from January to December 2022, with a total of 16,914 clinical isolates acquired from different clinical specimens from surgical and emergency ICUs at Zagazig University Hospitals. Results: Gram-negative bacteria were the most commonly identified pathogens (84.27%), with Klebsiella pneumonia being the most often detected one with a 39.01% incidence, followed by Escherichia coli with a 14.56% incidence. Staphylococcus species were recovered from 2649 isolates, with hominis being the most common. Gram-positive bacteria were the most commonly isolated organisms in blood cultures, while K. pneumoniae was the most commonly isolated pathogen in sputum, urine, and wound cultures. Colistin is the most effectively used antibiotic, with sensitivity for K. pneumoniae, E. coli, P. aeruginosa, and Acinetobacter of 95, 89, 92, and 85%, respectively. As regards the sensitivity to tigecycline, it was 87% for E. coli, 76% for Acinetobacter, and 75% for K. pneumonia. However, the sensitivity of carbapenem for these organisms was remarkably low. Conclusion: Our study provided local baseline epidemiological data that reveals the scope of our tertiary care hospitals' ICU infection problem. It provides valuable information on common microbial infections and their antimicrobial susceptibilities.