Abstract Background Unfavorable fetal, neonatal, and maternal outcomes are more likely to occur in pregnancies complicated by hypertension. The degree of awareness regarding health circumstances and locus of control on health is a highly significant component in determining the effectiveness of adherence to therapy, which is influenced by determinant factors. Aim Assess the effectiveness of nursing intervention session on health locus of control and self efficacy for women with preeclampsia. Method Two group quasi-experimental study design was used in outpatient units of all Port Said City obstetric hospitals that adhere to the comprehensive health insurance. A purposive non-probability sample of one hundred and fifty pregnant women. A structured self administered questionnaire, the multidimensional health locus of control scale and general self efficacy scale. Results Following nursing intervention sessions, pregnant women with preeclampsia in study group obtain higher mean score of internal, external powerful others of locus control on health and self efficacy (22.373 ± 9.316, 24.866 ± 7.323 & 15.640 ± 5.116) compared to the control group (20.866 ± 9.969, 23.640 ± 8.105 &12.080 ± 6.803) who didn’t not take part in nurse intervention sessions, with a statistically significant difference (p = 0.000) between the groups under study. Moreover, the study group’s external chance of health locus control mean scores were greater (21.013 ± 9.047) than the control group (19.946 ± 10.628) with none a noticeable difference between the groups under study. Conclusion In women with preeclampsia, nursing intervention can have a positive impact on all aspects of locus of control over health and self efficacy.