Background and objectives SLE is a debilitating chronic disease that affects patient's quality of life in many aspects. Besides its tendency to affect female more than male, SLE has very annoying skin manifestations, also it affects patients' body weight and has psychiatric and emotional impacts. SLE has a very bad impact on BI by various ways; moreover its physical consequences, it causes emotional effects such as anxiety and depressive mood. So in our study, we aimed to evaluate SLE impacts on BI acceptance and on patient's quality of life. a Methods: our study conducted on 39 SLE patients and 39 apparently healthy individuals as a control group. Patients were assessed by clinical history, general examination, musculoskeletal and SLEDAI-2K score for disease activity. All participants evaluated by World Health Organization Quality of Life Scale and The Body Dysmorphic Disorder Examination (BDDE) which is semi-structured clinical interview designed to diagnose body dysmorphic disorder and to measure symptoms of severely negative body image. Results: A significant differences between cases and controls were evident in body image and physical domain of QOL at p value 0.00 and 0.002 respectively. Insignificant associations were detected between body image and disease related factors, p value > 0.05. A significant correlation between body image and psychological and environment domains of quality of life in cases group at p value 0.006 and 0.009 respectively. Conclusion: SLE affects patients' body image acceptance and physical element of patient's quality of life with impact of body dysmorphic disorders on psychological and environment domains of quality of life