ABSTRACT Background: Obesity causes around 4.7 million preventable deaths worldwide each year. It is more challenging to calculate the burden of obesity since it is a consequence of its comorbidities rather than a direct effect. This research aims to assess the effectiveness of staple line reinforcement vs traditional sleeve gastrectomy. Patients and methods: This randomized controlled trial was conducted at General Surgery Department, Zagazig University Hospitals during the period from February 2023 to November 2023. This study was conducted on 30 patients with morbid obesity. All patients were divided into 2 equal groups, staple line reinforcement by over sewing group and No reinforcement group each group contain 15 patients. Results: There is statistically insignificant difference between both groups regarding their Pre-operative associated comorbidity and pre-operative anthropometric measures. There is statistically significant difference between both groups regarding operation duration where group A longer than group B. There is statistically insignificant difference between both groups regarding their postoperative complications. There was statistically insignificant difference of patients Weight, BMI, percent of Weight loss 6months post-operative of both groups (p>0.05). Conclusion: A promising method for lowering morbidity and the rate of gastric leakage is laparoscopic sleeve gastrectomy with staple line reinforcement.