Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
LncRNA LYPLAL1, miR-204-5p, and SIRT1: novel signatures for risk assessment of diabetic macrovascular complications
Faculty
Medicine
Year:
2024
Type of Publication:
ZU Hosted
Pages:
Authors:
Marwa Mohamed Ibrahim Atya
Staff Zu Site
Abstract In Staff Site
Journal:
Scientific reports Nature
Volume:
Keywords :
LncRNA LYPLAL1, miR-204-5p, , SIRT1: novel signatures for
Abstract:
Long-term, uncontrolled diabetes mellitus can lead to micro- and macrovascular problems. The protective function of lncRNA LYPLAL1 is to reduce endothelium cell inflammation by upregulating sirtuin 1 (SIRT1) and reducing microRNA (miR)-204-5p. This work attempted to examine the lncRNA LYPLAL1/miR-204-5p/SIRT1 molecules as diagnostic biomarkers for diabetic MVC and to assess their clinical correlations. The study enrolled 32 controls, 32 patients with diabetes alone, and 32 patients with diabetic MVC. RT-qPCR, or quantitative real-time PCR, was utilized to determine the expression levels of lncRNA and miR. SIRT1 was measured by ELISA. When comparing cases with MVC to those without MVC, the lncRNA LYPLAL1 and SIRT1 values were significantly lower. Conversely, patients with MVC had significantly higher miR-204-5p levels than those without MVC. The LncRNA LYPLAL1 performed best in terms of detecting MVC. It attained 90.6% specificity and 96.9% sensitivity. A combination of three markers (lncRNA LYPLAL1, miR-204-5p, and SIRT1) yielded the best accuracy at 98.4%. LYPLAL1 expression appeared to be an independent MVC predictor. Adjusted OR for LYPLAL1 expression was 405 (95% CI: 1.4–1200) (p = 0.039). When we compared cases with MVC to those without MVC, the lncRNA LYPLAL1 and SIRT1 values were significantly lower. Patients with MVC had significantly higher miR-204-5p levels than those without MVC. LYPLAL1 LncRNA demonstrated the best performance characteristics. LncRNA LYPLAL1 expression is an independent predictor of MVC.
Author Related Publications
Marwa Mohamed Ibrahim Atya, "Peripheral blood expression of matrix metalloproteinases-2,-9 and tissue inhibitor of matrix metalloprotinases-2 as molecular markers for diagnosis and staging of bladder cancer in Egypt", IJAR, 2015
More
Marwa Mohamed Ibrahim Atya, "Microrna-150 and Microrna-101 As Diagnostic Markers for Hepatitis B Virus Related Hepatocellular Carcinoma in Egypt", SciTechnol, 2017
More
Marwa Mohamed Ibrahim Atya, "piRABC and TNFSF4 as biomarkers for diagnosis and staging of bladder cancer.", Zagazig University, 2024
More
Marwa Mohamed Ibrahim Atya, "Infection index: a promising additive tool in detecting bacterial colonization", Wolters Kluwer - Medknow, 2021
More
Marwa Mohamed Ibrahim Atya, "VPS13C and STING expression in neuropsychiatric systemic lupus erythematosus: unveiling an unbreached territory", BMJ group, 2024
More
Department Related Publications
Rania Ahmed Khalil Ghonem, "The Rate of Extended-Spectrum B-Lactamases among Commonly Isolated Enterobacteriaceae in Cancer Patients in Zagazig University Hospitals", Scientific & Academic Publishing. All Rights Reserved, 2017
More
Rania Ahmed Khalil Ghonem, "Study of Minimal Residual Disease in Adults with B-Lineage Acute Lymphoblastic Leukemia by Flowcytometry", Journal of Cancer Therapy,, 2017
More
Amal Ahmed Ali Zedan, "Role of Serum Midkine Level as a Diagnostic Biomarker for Very Early and Early Hepatocellular Carcinoma", Endemic and Tropical Medicine Department . Zagazig University, 2018
More
Amany Mohamed Mohyldeen, "Neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in Behçet’s disease: which and when to use?", International League of Associations for Rheumatology, 2018
More
Amany Mohamed Mohyldeen, "Vitamin D Status in Hemophilia Patients Attending at Zagazig Universty Children Hospitals", Faculty of Medicine-Zagazig Universi, 2020
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف