Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Impact of Prognostic Nutritional Index and Systemic Immune-Inflammation Index on the Clinical Outcome of Diffuse Large B Cell Lymphoma Patients Treated with RCHOP
Faculty
Medicine
Year:
2024
Type of Publication:
ZU Hosted
Pages:
Authors:
Marwa Mohamed Ibrahim Atya
Staff Zu Site
Abstract In Staff Site
Journal:
ZUMJ Zagazig University
Volume:
Keywords :
Impact , Prognostic Nutritional Index , Systemic Immune-Inflammation
Abstract:
Background: The most frequent lymphoma in Egyptian adults is diffuse large B-cell lymphoma (DLBCL). Patients with DLBCL experienced a wide variety of prognoses. It has become challenging to identify high-risk groups using IPI alone because the outcome of DLBCL patients has improved with the introduction of rituximab. It would thus be important to find prognostic indicators for predicting patient subgroups with poor prognosis and choose the efficient therapy regimen in accordance. One of the factors thought to contribute to the formation of cancer metastases and cancer progression is inflammation. The systemic immune inflammation index (SII) is a reliable indicator of cancer patients' prognosis. It seems that nutritional status affects how different solid tumors behave. To evaluate the immunological nutritional condition of cancer patients, the Prognostic Nutritional Index (PNI) was developed. The goal of our research was to assess SII and PNI's prognostic and predictive significance in DLBCL patients receiving RCHOP therapy. Method: This prospective, non-randomized study aimed to evaluate the prognostic value of SII and PNI in patients DLBCL receiving RCHOP. Eightyfour patients were included. Results: The optimal cut-off values for PNI and SII using the ROC curve were 50 and 410, respectively. PNI and SII were significantly associated with a complete remission rate. Multivariate analyses showed that low PNI and high SII were independent predictors of poor relapse-free and overall survival. Conclusions: A growing body of evidence demonstrates the value of pretreatment PNI and SII as simple prognostic indicators in DLBCL patients receiving RCHOP.
Author Related Publications
Marwa Mohamed Ibrahim Atya, "Peripheral blood expression of matrix metalloproteinases-2,-9 and tissue inhibitor of matrix metalloprotinases-2 as molecular markers for diagnosis and staging of bladder cancer in Egypt", IJAR, 2015
More
Marwa Mohamed Ibrahim Atya, "Microrna-150 and Microrna-101 As Diagnostic Markers for Hepatitis B Virus Related Hepatocellular Carcinoma in Egypt", SciTechnol, 2017
More
Marwa Mohamed Ibrahim Atya, "piRABC and TNFSF4 as biomarkers for diagnosis and staging of bladder cancer.", Zagazig University, 2024
More
Marwa Mohamed Ibrahim Atya, "Infection index: a promising additive tool in detecting bacterial colonization", Wolters Kluwer - Medknow, 2021
More
Marwa Mohamed Ibrahim Atya, "VPS13C and STING expression in neuropsychiatric systemic lupus erythematosus: unveiling an unbreached territory", BMJ group, 2024
More
Department Related Publications
Mona Elsayed Hashim Muhammad, "Common MEFV Mutations Analysis in Egyptian Patients with Familial Mediterranean Fever", ELSEVEIR, 2010
More
Mona Elsayed Hashim Muhammad, "Serum Soluble transferrin receptors concentration as an accurate estimate of body iron store over serum ferritin in patients of type 2 diabetes", جامعة الازهر, 2010
More
Mage Munir Hussein Fawzi, "Association of ficolin-2 gene polymorphisms and susceptibility to systemic lupus erythematosus in Egyptian children and adolescents: a multicenter study", SAGE Journals, 2019
More
Weaam Ibrahim Ismail Ali, "Assessment of INPP4B Expression Level in Acute Myeloid Leukemia Patients and Its Prognostic Significance. An Egyptian Study", https://ejhm.journals.ekb.eg/, 2021
More
Amal Ahmed Ali Zedan, "Vitamin D Receptor Gene Polymorphism as a Prognostic Marker in Acute Myeloid Leukemia Patients", www.ijpras.com, 2018
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف