ABSTRACT Background: Histological analysis is used to distinguish between benign and malignant tumors, allowing for the definitive diagnosis of soft tissue sarcoma (STS). Objective: To evaluate the clinicopathological characteristics of extremity soft tissue sarcoma. Subjects and Methods: The present cross-sectional study included a total sample of 18 participants with soft tissue sarcoma planned for surgery according to their tissue biopsy. Results: Regarding the characteristics of STS in the present results, the mean size was 20.1± 10.6 cm, ten patients (55.6%) had STS on the right side and 44.4% had STS on the left side. Only five patients (27.8%) had superficial STS and 13 (72.2%) had deep STS. Regarding the stages of STS, 2 (11.1%) were stage IA, 3 (16.7%) were stage IB, 4 (22.2%) were stage IIA, 6 (33.3%) were stage IIB, 1 (5.6%) was stage IIIA and 2 (11.1%) were stage IIIB. Regarding the histopathological diagnosis of STS, 2 (11.1%) had undifferentiated pleomorphic sarcoma, 3 (16.7%) had liposarcoma, 7 (38.9%) had rhabdomyosarcoma, 3 (16.7%) had myxofibrosarcoma, and 3 (16.7%) had leiomyosarcoma. The comparison between males and females regarding characteristics and histopathological types of STS showed that there was no statistically significant difference. Conclusion: Males are more likely to be diagnosed with soft tissue sarcoma, while middle-aged people are disproportionately afflicted. The lower extremities are the most prevalent site of involvement, and rhabdomyosarcoma is the most common histologic subtype. The clinicopathological features of soft tissue sarcoma are not influenced by gender distribution.