Antimicrobial and anti-virulence activities of 4-shogaol from grains of paradise against gram-negative bacteria: integration of experimental and computational methods

Faculty Pharmacy Year: 2024
Type of Publication: ZU Hosted Pages:
Authors:
Shaima Ibrahim Nazeh Muhammad Ali
Journal: Journal of Ethnopharmacology Elsevier Volume:
Keywords : Antimicrobial , anti-virulence activities , 4-shogaol from grains    
Abstract:
Ethnopharmacological relevance Bacterial resistance to antibiotics is a growing global concern, highlighting the urgent need for new antimicrobial candidates. Aframomum melegueta was traditionally used for combating urinary tract and soft tissue infections, which implies its potential as an antimicrobial agent. Aim of study This study was designed to explore the antibacterial and anti-virulence capabilities of 4-shogaol isolated from A. melegueta seeds versus gram-negative bacteria: Serratia marcescens, Klebsiella pneumoniae, Acinetobacter baumannii, and the clinically important pathogen Pseudomonas aeruginosa. Materials and methods 4-Shogeol was isolated from A. melegueta seeds and its MICs were determined for Acinetobacter baumannii (ATCC-17978), Pseudomonas aeruginosa (ATCC-27853), Klebsiella pneumoniae (ATCC-700603), and Serratia marcescens clinical isolate. The anti-efflux activity and …
    
     
 
       

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