In this study, the structural performance of reinforced concrete frames strengthened with external post-tension tendons was investigated. An experimental study was performed to investigate the failure modes and generate the data required to validate the numerical model. The experimental study includes a reinforced concrete (RC) frame control specimen without strengthening and three strengthened specimens under vertical loads. The specimens were strengthened using external post-tensioning with three different tendon layouts, including a straight tendon in the beam-positive moment zone, straight tendons in the beam-positive and column-negative moment zones, and U-shape tendons along the frame beam. The numerical model was built for the four specimens, validated using the experimental results, and used to analyze the lateral load performance. Results showed that the most effective strengthening technique for the vertical load was the beam U-shape tendons, and for the lateral load, it was the beam and column strengthening. It can be concluded from this case study that strengthening frames with external post-tensioning techniques can enhance the first crack load, yielding load, and ultimate load by 80–100 %, 180–250 %, and 35–70 %, respectively.