Understanding the dynamics of insulin therapy in type 2 diabetes is crucial for the effective management of the disease. This review navigates through the evolution of insulin formulations, emphasizing the impact of different regimens on patient-reported outcomes. Adherence to insulin therapy, a pivotal factor for successful outcomes, is investigated alongside various insulin preparations and the influencing factors. Gaining insight into these dynamics can steer healthcare strategies, ultimately refining decision-making and boosting patient outcomes in type 2 diabetes management.