This study presents a comprehensive analysis of mineralization exploration in the Egyptian Eastern Desert (ED), one of the most sought-after areas for those interested in mining industry, by integrating Landsat-9 images and geophysical magnetic data. Employing advanced techniques like Principal Component (PC) analysis, Minimum Noise Fraction (MNf) transform, and Band-Ratio (B-Ratio), the research focuses on mapping lithological units, hydrothermal alteration regions, and structural elements. Composite images derived from specific PC, and MNf bands, and B-Ratio exhibit superior lithological unit identification. The findings emphasize that there are significant variations in the types of rocks extend from the southern to the northern parts of the ED. Hydrothermal alteration mapping, guided by B-Ratio results, aids qualitative lithological discrimination. A novel false color composite image optimizes Landsat-9 B-Ratios, enhancing rock unit discrimination. Correlation analyses reveal associations between mineralization types and major lithological units, while exploration of the magnetic anomaly map highlights its role in correlating mineralization sites. Structural features, analyzed through Center for Exploration-Targeting Grid-Analysis (CET-GA) and Center for Exploration-Targeting Porphyry-Analysis (CET-GA) with Tilt Derivative of RTP (TDR) techniques, contribute to a robust association between regions with medium to high structural density and porphyry intrusions and mineralization. The study significantly supports the advanced exploration geoscience, providing insights into the geological structures and dynamics governing mineralization in the Egyptian ED.