Abstract. – OBJECTIVE: Chronic low-grade inflammation has emerged as a key contributor to the pathogenesis of Polycystic Ovary Syn￾drome (PCOS). In this regard, the present study examined the potential effects of aerobic exer￾cise on interleukin-6 (IL6), tumor necrosis fac￾tor (TNF), and C-reactive protein (CRP) in PCOS women. PATIENTS AND METHODS: This was a ran￾domized clinical trial that included 40 females aged 25-35 years diagnosed with PCOS. The participants were divided into two groups equal in number: the aerobic exercise group (AEM), and the metformin group (M). The AEM group performed aerobic exercise three times a week for 12 weeks in addition to metformin treatment. The M group received metformin only. Partici￾pants were assessed for IL-6, TNF-α, and CRP at baseline and after 12 weeks of intervention. RESULTS: The findings showed a significant reduction in IL-6, TNF-α, and CRP values in both AEM and M groups (p=0.001, p=0.01, respec￾tively) after the end of the 12 weeks of the in￾tervention. However, the participants who re￾ceived aerobic exercise plus metformin, group AEM, showed a greater reduction in IL-6, TNF-α, and CRP (p=0.01, p = 0.01 and p=0.001, respec￾tively). CONCLUSIONS: Aerobic exercise is effective in lowering IL‐6, TNF‐α, and CRP in polycystic ovarian women. Further clinical trials are recom￾mended to assess the potential effects of aero￾bic exercise on PCOS-associated risk factors.