Background:Cystic lesions of the kidney are relatively frequent and may represent benign cysts, Premalignant lesions, or malignant neoplasms. When asingle layer of cuboidal or flattened cells lines a cystic lesion, they are considered simple renal cortical cysts. Aim of The Work: Our study aims to determine the frequency and associated risk factors of renal cysts. Patients & Methods: A cross-sectional study including 242 subjects undergoing abdominal CT, aging more than 18 years, and with no history of medical diseases. All involved patients were subjected to Routine investigations, including Random blood sugar, postprandial blood glucose., HbA1c, Complete blood picture, Serum creatinine, urea, and cholesterol in addition to Complete Urine analysis. All participants were subjected to Computed tomography (CT) abdomen. Results:18.6% of the studied group had Pyuria, 29.5% had Urate crystal, 14% had microscopic hematuria, 1.2% had gross hematuria, and 29.3% had proteinuria. 20.2% (49 cases) had cyst among the studied population. Cyst cases were significantly associated with older age, male sex, smoking, diabetes mellitus, hypertension, and longer duration of treatment of DM and HTN. RBS, 2PP BS, HbA1C, Cholesterol, Cr, and Urea were significantly higher among cases with the cyst. Also, cases with cysts were significantly associated with Pyuria and Proteinuria. Conclusion: Significant risk factors for the occurrence of renal cysts include older age, male sex, hypertension, diabetes mellitus, smoking, longer DM or HTN TTTduration. Serum Urea, Creatinine, Cholesterol, urinary Pus, and Proteinuria are also significant factors affecting Renal cysts. However, BMI, chronic use of NSAIDs, CBC findings, urate crystals, and hematuria are not statistically significant factors affecting renal cysts.