Background: Endothelial cells have an abundance of the receptor Tyrosine Kinase Tie2. Proteolytic cleavage and ectodomain release generate soluble Tie2 in Covid19 patients. Aim: to study role of Tie2 expression in coagulopathy associated COVID19 patients with and to evaluate the impact of this on disease outcome. Subjects and methods: our study was conducted at Clinical Pathology Department and quarantine unit of Internal Medicine Department, it was a case control study on 50 patients with Covid19 having coagulopathy compared to 50 alike healthy controls admitted to Zagazig University Hospitals. Patient history, physical examination, routine laboratory tests, and flowcytometric evaluation of Tie2 expression were all performed to each participant. Results: there was statistically significant relation between the studied groups regarding platelet count (lower in case group), while all of prothrombin time, INR, partial thromboplastin time, serum ferritin, CRP, LDH, procalcitonin, D dimer, ESR and IL-6 were statistically significant higher in the case group. There was statistically significant relation between the studied groups regarding Tie2 expression (higher in case group). The primary outcome was evaluated at the end of the hospital stay and the patient group was sub-grouped into survivors and non-survivors. Out of the 50 study patients, 21(42%) were survivors and 29 (58%) were non-survivors. There was a statistically significant relation between outcome of case group and Tie2 expression (significantly higher in non-survivors patients). Conclusion: Tie2 may be an early and useful predictor of COVID19 clinical course, and it could be a relevant part of disease pathogenesis.