Pyometra is regarded as a serious issue that poses a threat to the life of queens. The risk of pyometra brought on by toxicity and the incidence of septicemia. The most effective and conventional treatment for pyometra is surgical removal of the pus source (the female reproductive tract) which known as spaying operation (ovariohysterectomy). However, medical treatment may be applied if maintaining reproductive ability is desired. In the present study, 30queens were employed and split into 2groups. In G1 (n:15), queens received 1μg /kg/24 h of PGF2α intramuscularly and (half tab/day/orally) of Amoxicillin-Clavulanate 1g (chosen based on the result of sensitivity test) for 7 days. Cats in group 2 (n=15) received the same therapy as group 1 with the addition of oral dopamine agonist (5 μg /kg/24 h). The general health condition of the queen and the presence of genital discharge was followed up during the treatment period. the recurrence of this problem was recoded every 4 months. Additionally, the diameter of uterine horns was assessed daily using ultrasound from the beginning of the treatment. After receiving treatment for one week, queens inG1 and G2 no longer had any clinical signsof pyometra or genital purulent discharge. Six cats (40%) in G1 showed their first recurrent pyometra on within 4monthsafter the start of treatment. But four cats (26.6%) in G2showedthe first recurrence between the 4th and 8th month after the first treatment. The returned cats from the second treatment trial, were exposed to ovariohysterectomy and then apply the histopathological examination. In conclusion, using cabergoline with PGF2αachiever more rapid involution of the uterus and lower recurrence rate than using PGF2α alone. ا