Triple negative breast (TNBC) cancer is a distinct subtype of BC that is characterized by frequent recurrence and metastasis. It is suggested that androgen receptor (AR) may be a valuable prognostic marker in TNBC. Aim of work: To assess the relation between AR and clinicopathological features. Methods: This retrospective study included 35 patients with non-metastatic TNBC treated at Medical Oncology Department, Maadi Armed Forces Medical complex from January 2015 to June 2019. All patients were subjected to full documentation of their history. The general and local examination were the two main components of the clinical examination done for all subjects. Some laboratory investigations were performed. All patients underwent preoperative imaging tests. Immunohistochemistry was performed on Formalin fixed Paraffin Embedded tissue sections from tumor specimens using standard procedure to evaluate AR expression more than 1% of tumor cells nuclei stained were considered positive. Results: Low proliferative index was more frequent in patients with positive AR than those with negative AR (6/13; 46.2% vs 1/22; 4.5%, respectively) while High proliferative index (Ki 67 > 20 %) was more frequent in patients with negative AR than those with positive AR (19/22; 86.4% vs 7/13; 53%, respectively), a statistically significant difference (P = 0.009).Conclusion: Triple-negative breast cancer is an aggressive disease with mixed heterogenicity associated with poor prognostic outcome. Androgen receptor positivity was associated with lower risk of disease recurrence and mortality. … Methods Top methods in this publication Top related publications View more methods papers