Background: Fatigue, myalgia, and arthralgia are the typical COVID-19 musculoskeletal symptoms, but their prevalence has not been studied extensively. This study was designed to estimate the frequency of different musculoskeletal symptoms among COVID-19 patients and determine the association between the musculoskeletal symptoms and some Sociodemographic characteristics and the severity of the disease. Methods: A cross-sectional study was conducted among 160 (COVID-19) patients attended screening clinic at Zagazig university hospitals during a period from15-4-2020 to 15-7-2020, they were drown by systemic random method. Clinical assessment was done by taking of sociodemographic data, assessment of the severity of COVID symptoms and assessment of the musculoskeletal through Joint assessment and Fatigue assessment. Results: The majority of patients developed fatigue and myalgia (60.0%), arthritis, or arthralgia was reported in (47.5%, 45.0%) of patients had back pain. According to Nordic questionnaire, most of studied patients were suffering from musculoskeletal manifestations at neck, lower back, and knee (55.0%, 54.0% and 50.0%) respectively. There was a statistically significant association between arthralgia and sex distribution (p=0.0001) where (61.9%) of females had arthralgia. There was a statistically significant association between myalgia and occupation of the patients (p=0.000) where 82.4% of mentally working patients had myalgia. Binary logistic regression analysis revealed significant models for the prediction of myalgia, fatigue and arthritis/arthralgia. Conclusions: Musculoskeletal symptoms associated with COVID-19 patients are frequent mostly fatigue and myalgia followed by arthritis or arthralgia, and back pain. Patients with comorbidities were significantly associated with fatigue. Females had arthralgia more than males. Also, a high percent of mentally working patients from urban were complaining of back pain. Keywords: Musculoskeletal; Frequency; Risk Factors; COVID-19