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Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?
Faculty
Medicine
Year:
2024
Type of Publication:
ZU Hosted
Pages:
e37356
Authors:
Ahmed Abdelsabour Mohamed Moussa
Staff Zu Site
Abstract In Staff Site
Journal:
Medicine LWW
Volume:
103
Keywords :
Late onset neonatal sepsis: , plasma gelsolin
Abstract:
Plasma gelsolin (pGSN) correlates with clinical improvement in septic patients. We aimed to investigate pGSN levels as a diagnostic and prognostic marker of neonatal late-onset-sepsis (LOS). A case-control study was done on 184 neonates (92 with LOS and 92 controls). All participants were subjected to detailed history taking, full clinical evaluation, sepsis workup, and pGSN enzyme-linked immunosorbent-assay measurement. We detected significantly lower pGSN level among cases compared to controls (90.63±20.64 vs 451.83±209.59). It was significantly related to the severity of sepsis and mortality, with significantly lower values among cases with septic shock and multiorgan failure and non-survivors. Follow-up pGSN significantly increased after sepsis improvement in survivors compared to admission values. pGSN might be a reliable diagnostic and prognostic marker for LOS.
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