This work was conducted to investigate the growth performance, hematological characteristics, and carcass merits in four duck breeds (Pekin, Star 53, Muscovy and Mulard ducks). A total 80 ducklings one day old were used in this work till the age of 12 weeks. Each of the ducklings was allocated to 4 replicates (5 ducks/ replicate). The obtained results denoted that the Mulard had the heaviest body weight (4234 gm) followed by Muscovy, Star 53 and Pekin (4029, 3659 and 2938 g., respectively). Muscovy ducks had a highly significant dressing percentage (84.39 %) compared to that of Mulard, Pekin and Star 53 (83.23, 74 and 72.72 %, respectively). Mulard duck had the highest values in Hemoglobin and MCHC by (25 and 49 %) in Pekin and Star but (32 and 24 %) in Muscovy. Lymphocyte in Muscovy increased about two times of Pekin, Star 53. Conclusion, performance, carcass characteristics, and blood parameters were all generally better with Mulard ducks. Keywords: Duck breeds, Performance, Carcass merits, Blood measurements.