"The continuous increase in technological advancement, utilization, and organization poses a challenging dilemma in the context of the Fourth Industrial Revolution (4IR). Concerns have been expressed regarding the sufficiency of human capital in this stage, especially in developing economies such as Egypt. This research employed an analytical and descriptive methodology to evaluate the readiness of human capital in the Fourth Industrial Revolution era. The study utilized a Threshold Regression analysis to determine the threshold or barrier that the level of accumulated human capital must surpass to significantly impact the Fourth Industrial Revolution. The methodology takes into consideration factors such as current levels of education and health, technological innovation variables, and anticipated changes in the job market. The results revealed a positive impact of accumulated human capital on embracing 4IR, manifested in the levels of network readiness and economic complexity of the studied countries. However, the strength of this relationship varied based on the level of accumulated human capital (threshold level), ranging between 3.19 and 3.22 concerning economic complexity and network readiness, respectively. In comparison with the level of accumulated human capital in Egypt up to the year 2020, which stood at 2.707, it became evident that the minimum required threshold for accommodating Fourth Industrial Revolution applications slightly exceeds Egypt's level of accumulated human capital. Therefore, policymakers and stakeholders should prioritize investing in the development of human capital, including skills enhancement programs and healthcare initiatives, to ensure a strong readiness for leveraging the opportunities available within the framework of 4IR (Industry 4.0)."