Health-promoting lifestyle practices, have been shown to have a beneficial effect on CKD progression The aim of the study was to assess factors affecting health promoting lifestyle practices among elderly patients with chronic kidney disease. Research design: A descriptive design was utalized. Setting: This study was conducted at inpatient renal ward in Internal Hospital at Zagazig University Hospital. The tool of data collection three tools was used Tool I: A structured interview questionnaire sheet consisted of two parts; Part one: Demographic characteristics of the studied elderly patients, Part two: Health profile of the studied elderly patients. Part three: patients′ knowledge about chronic kidney disease. Part four: perceived social support assessment Tool II: self-efficacy scale Tool III: Health-Promoting Lifestyle Profile II. The results of the current study revealed that studied elderly patient's age ranged between 60 and 79 years, with mean 66.50 ± 4.24. (77%) of studied elderly had satisfactory knowledge about CKD. 70% of studied patients had Moderate Level of health promotion lifestyle practices. Finally, there was statistically significant difference between health promoting lifestyle practices and age, gender, educational level, history of having hemodialysis, number of chronic diseases, knowledge about disease, self-efficacy and social support with p value (0.005, 0.019, 0.00, 0.018, 0.00, 0.004, 0.00, 0.003 consecutively). The study concluded that variables affecting the scoring of health promoting lifestyle practices were age, gender, educational level, number of chronic diseases, knowledge about disease, self-efficacy and social support. Recommendation: implement educational program about health promoting lifestyle practices for CKD.