Background: Minor ailments/disorders are only minor as much as they are not life threatening. As soon as a women become pregnant and experience that fatigue of early pregnancy coupled with nausea and vomiting. A minor ailment may escalate and become a serious complication of pregnancy. They are heart burn, excessive salivation, pica, constipation, back ache, cramps, frequency of micturition, leucorrhea, fainting and insomnia. Aims of this study are to: evaluate the effect of utilization of nursing guideline and assisted teaching videos on knowledge& self-care reported practice for alleviation of minor ailments among primigravida mothers through the following; assessing the knowledge and self-care practice of them& designing and implementing these guideline and teaching videos according to women’ needs and finally evaluating the impact of these on knowledge and personal - care practice regarding management of minor discomfort. Subjects and Methods: Research design: quasi- experimental design was used to the current research. Setting: The study was conducted at Obstetric Outpatient clinics at zagazig University Hospital, Subjects: a total of 100 primigravida mothers were recruited in the study. Tools of data collection: Three tools were used for data collection; structured interviewing questionnaire, knowledge assessment questionnaire & self-care reported practice assessment questionnaire. Results: results indicated that the score of mothers’ knowledge and practice before and after the program implementation was satisfactory with statistically significant differences. Conclusion: The study concluded that, the knowledge & self-reported practice level of the pregnant mothers under the study were significant improved regarding the management of minor discomforts by using standard nursing guideline& video assisted teaching. Recommendations: based on the findings of this research the following recommendations are suggested: awareness campaigns & developing and implementing in the department of obstetrics & gynecology to support pregnant women in order to alleviate minor discomfort during pregnancy. Key words: Nursing guidelines and assisted teaching videos; Minor Ailments; Primigravida