Promoting ideal cardiovascular health is one strategy to promote health equity for adult smokers. Aim: This study aimed to evaluate the effect of strategic plan to promote cardiovascular health and wellness regarding adults smokers. Design: A quasi experimental research design was used. Setting: This study was conducted at out-patients cardiology clinics, allied to Zagazig University Hospital. Sample: A Purposive sample of 80 patients, 40 randomly assigned to each group study and control groups. Tools: Patients' interview questionnaire, The cigarette dependence scale, Self-reported dietary adherence questionnaire, Physical activity assessment questionnaire, and The Warwick-Edinburgh Mental Well-being scale. Results: The most of patients in the study group (90.0%) had normal pulse rate and blood pressure post intervention, the majority (80.0%) had clear breath sound, and three quarters (75.0%) had not chest pain. There was a highly statistically significant difference between study and control group post intervention concerning total knowledge, cigarette dependence, dietary adherence, physical activity, and mental well-being at p<0.001. Conclusion: According to study findings, the level of Knowledge, cardiovascular health, dietary adherence, cigarette dependence, physical activity, and mental well-being among the study group patients was improved post intervention compared to pre intervention. Statistically significant differences happened between both groups considering Knowledge, cardiovascular health, dietary adherence, cigarette dependence, physical activity, and mental well-being, which supported the stated hypothesis. Recommendations: Additional study on larger probability sample is recommended for general capacity. Keywords: Cardiovascular, Health, Smokers, Strategic Plane and Wellness