Abstract Background: High-quality diabetes self-management education has been shown to improve patient self-management, satisfaction, and glucose outcomes. Objective: this study aimed to assess the effect of self-management diabetes education program on metabolic control indicators among type 2 diabetes mellitus patients. Method: An interventional randomized controlled trial was carried out at an outpatient diabetes clinic in a tertiary level hospital, Egypt. A total of 76 adult type 2 diabetic patients were recruited, 70 (92.1%) patients completed the study. In pre and post-intervention phases, data were collected to assess; sociodemographic characteristics; metabolic indicators; glycosylated hemoglobin in both groups at the beginning of the study and 3 months after the intervention. In the intervention phase, a self-management 5A model was applied to the intervention group while the traditional group continued routine treatment and traditional health education. The effects on metabolic indicators were assessed between groups after the intervention. Results: At baseline, both intervention and traditional groups were matched regarding risk factors of diabetes and sociodemographic characteristics. Glycosylated hemoglobin and other metabolic parameters showed no significant differences between both groups before intervention. This study revealed significant improvement in metabolic indicators after intervention among the intervention group compared to the traditional one regarding fasting blood glucose level, HbA1C level, total cholesterol, and other lipoproteins as well respectively. Diabetes selfmanagement questionnaire scores were significantly improved after intervention among cases compared to controls (p<0.001). Conclusion: This study explored the effectiveness of using the 5A model of self-management in improving metabolic control indicators in type 2 diabetic patients.