Background and objective: Changing the patient lifestyle as regarding diet well helped in vitiligo patient cure. Aim: to examine the effect of applying dietary instructions on dietary lifestyle modifications of vitiligo patients. Methods: Research design: Quasi experimental research design with one group (Pre/Post-test) was utilized in this study. Setting: the study was conducted in the ultraviolet unit at the Dermatology Department of Asyut University Hospitals. Study tool: Structured patient interview questionnaire sheet. It included two parts: Part 1: Assessment of patient’s sociodemographic variables. Part 2: Dietary pattern assessment: derived from Patient Life Style Pattern Assessment Sheet (PLSPAS) for Vitiligo. Results: The mean age of the studied sample was (mean ± SD 34.62 ± 12.35), 51.6% were female, 70% were living in rural areas, a highly statistically significant difference in the total mean knowledge scores between pre and post application of the dietary instructions (p value = .002). Conclusions: The present study concluded that there was a great improvement in the dietary lifestyle pattern of the studied sample after application of dietary instructions. Recommendations: Replication of the study on a larger probability sample from different geographical locations for generalization of the results. Printing copies of the dietary instructions for dissemination among all vitiligo patients attending the dermatology ward for treatment or follow-ups.