Background: Self-care practices is a process by which individuals and families use knowledge and beliefs, self-regulation skills and abilities, and social facilitation to achieve outcomes of health especially during pregnancy. Aim: The aim of the present study is to identify pregnant women self-care practices in early pregnancy. Subjects and Methods: The study was carried out at ante-natal clinics in fourteen primary health care centers representing the six districts in Port-Said city using a cross-sectional descriptive design. The study subjects consisted of 350 users of antenatal care services. An interview schedule was designed and utilized to collect the necessary data. Results: The finding of the current study revealed that nearly all women lacked basic and essential information about antenatal care. Thus a lot of more than two thirds (68.0%) had a shower twice weekly, and 78.0% washed their breasts with soap and water, and 55.6% brushed their teeth with water only. Suitable clothes were used by only 53.4%, and 46.0% had insufficient hours for night sleep, while, 41.4% consumed adequate diet. However, almost all (77.4%) of the studied group had been immunized against tetanus during the current pregnancy. As for minor discomforts of pregnancy 58.6% had morning sickness and 37.1% endured constipation as well as insomnia 58.6% and heaviness of the breasts (38.0%). Traditional, harmful and harmless practices were utilized in coping with all discomforts of pregnancy. Recommendations: Nurses must certainly be competed in counseling women that are pregnant about their needs and self-care management and encouraged to make use of information guide as an excellent educational tool in counseling them. Conclusion: women were lacking essential and basic knowledge about physiological and psychological adaptation to pregnancy and consequently their self-care requisites and health deviations from normal and how to deal these discomforts.