Background: Coronavirus disease 2019 (COVID-19) is a serious emerging public health issue and it has been identified as a major risk to human health in 2020. Egypt has more than 100 million population, of whom in poor economic conditions and with low education levels could be vulnerable to COVID-19 infection. Physicians are at the frontiers in battles against the emergence, spread, and control of COVID-19 pandemic. Research data are needed to develop evidence-based strategies to prepare health care systems to deal with the current epidemic. Aim: The aim of this study is to assess the level of knowledge and attitudes to COVID-19 pandemic among a group of Egyptian physicians. Methods: From March 15 th to March 25th, 2020, we conducted a cross-sectional online survey using non-probability accessibility sampling technique. The structured questionnaire was distributed online through E-mails and social networks to identify the knowledge and attitude among a group of Egyptian physicians regarding COVID-19 pandemic. Result: The study included 256 physicians. Of the participants, 48% were males 49.6% were females. The mean of total score was (19.6±2.3) out of 23 gained mainly from the social media (50.7%). About 67% of the participants heard of Coronaviruses before this pandemic, 78.5% identified other Coronaviruses. All the participants correctly identified the incubation period and 81.6% correctly identified the typical clinical symptoms. Most of the participants (97.6%) could estimate the fatality of COVID-19. Approximately 95% of the respondents knew no vaccination and 88% correctly answered that no current specific treatment for COVID-19 available. Almost all 98% of the participants knew the recommended general infection control precautions. Most of the participants showed positive attitude, about (97%) agreed that health care workers must avail themselves of all information about the COVID-19. Conclusion: The finding of this survey indicating that, faced with the COVID-19 pandemic, this studied group of Egyptian physicians showed positive attitude and satisfactory knowledge about emerging COVID-19 infection. Recommendations: Although the Egyptian Ministry of Health (MOH) has taken several major steps to prepare the health care system to be ready dealing with COVID-19 pandemic, it is important to develop educational programs to ensure continuous updated knowledge of the physicians.