Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Oxidative stress (OS) plays a pathological role in the development of various diseases including obesity. The present study aims to investigate the effect of feeding some selected food industries by-products including potato peel powder (PPP) yellow onion skin powder (YOSP), eggplant peel powder (EPP) and their mixture (Mix) on the oxidants/antioxidant status, lipids profile and immunological parameters of blood obese rats. Thirty six (150±8 g per each) were divided into two main groups, the first group (Group 1, 6 rats) still fed on basal diet and the other main group (30 rats) was feed with diet-induced obesity (DIO) for 8 weeks which classified into five sub groups as follow: group (2), fed on DIO as a positive control; groups (3-6), fed on DIO containing 5 % of PPP, YOSP, EPP and Mix, respectively. At the end of the experiment (8 weeks), rats of the obese group recorded significant (p≤ 0.05) higher increasing in body weight gain (220.10%) than the normal group (177.83%). Hematological analysis data indicated that obesity induced a significant (p≤0.05) increasing in plasma oxidants concentration (NO2, 35.06%, NO2/NO3, 27.64%, and TBARS, 42.88%) and significant decreased (p≤0.05) in erythrocytes antioxidant enzymes (GSH-Px, 35.83%; CAT, -35.74% and SOD, 27.79%) and plasma antioxidant vitamins (vitamin A, 24.69%; vitamin C, 19.31% and vitamin E, 28.83%) as well as RBC's as a percent of normal group. Also, obesity induced a significant (p≤0.01) increasing serum lipid profile parameters (TG, 35.19%; TC, 30.10% and LDLP, 90.41%), serum glucose (31.54 %) and significant (p≤0.05) decreasing in serum immunological parameters (albumin, 10.28 and serum protease, 19.60%) as a percent of normal group. Feeding on 5 % of PPP, YOSP, EPP and Mix induced significant (p≤0.05) improvement in all of these parameters by different rates. The higher amelioration effects were recorded for the Mix treatment followed by YOSP, EPP and PPP, respectively. In conclusion, the present data provide a basis for the use of the selected food industries by-products in our daily diets to alleviate blood OS, immunological suppression, lipid profile changes and glucose elevation associated obesity.