This paper presents computational analyses for the peristaltic motion of nanofluids through a porous medium. The thermal conductivity and permeability of the porous medium are functions of a variable porosity. The non-homogeneous nanofluids model is applied to simulate the nanofluids behaviors and properties of the mixture are depending on the size and shape of the nanoparticles. Cases of a heat source/sink as well as the viscous dissipation influences are assumed to be significant during the formulation. The analyses of the wavy-channel entropy and comparing between the heat transfer and nanofluid friction irreversibility’s are performed. The major outcomes disclosed that the temperature, NP concentration, peristaltic flow and system entropy are enhanced as the viscous dissipation coefficient is altered. Also, the average NP parameter has positive influences on the temperature gradients. Further, as the heat generation parameter is enhanced, the peristaltic convective transport is enhanced owing to the increase in the temperature differences l