Background: Chronic kidney disease (CKD) is recognized as a leading public health problem worldwidewhich is more prevalent in the elderly population.However, there is paucity of studiesinvestigating muscle function in older adults with CKD.This study aimed to assess the function of upper and lower limb muscles in elderly patients with CKD. Methods: A case-control study was conducted, including 73 patients with CKD and 73 healthy individuals as a control group. Patients were subdivided into two groups; 37 predialysis patients and 36 patients on regular hemodialysis.History was taken, blood pressure, anthropometric measures, handgrip strength (HGS), timed up and go test(TUGT) were assessed anda blood sample was withdrawn for measuring complete blood count, random blood sugar, lipid profile, renal and liverfunction tests. Results: There is a significant decreasein HGS and a significant prolongation of TUGT in CKD patients as compared to the control group.PredialysisCKD patients have significantly higher HGS and less prolonged TUGT as compared to patients on regular hemodialysis.Both hemoglobin and albumin are positively correlated with HGS and inversely correlated with TUGT.Fasting triglycerides are inversely correlated with HGS. A highly significant inverse correlation was found between HGS and TUGT. Conclusions: There is a significant decline in upper and lower limb muscle function in CKD patients and this decline seems to be more obvious in lower limb muscles.The decline in muscle function is more evident in the hemodialysis than in the predialysis CKD patients.