Psoriasis is a chronic inflammatory skin disease with substantial genetic and autoimmune pathogenic aspects that significantly reduces the quality of life of individuals who suffer from it. Aim: Assess the effect of how psoriasis affects patients' life quality, stress, and disability. Research design: The study was carried out using a descriptive research approach. Sample: Purposive sample including all 33 patients with psoriasis was recruited in the study. Setting: The research was carried out at Zagazig University Hospitals' Outpatient Dermatology Clinic. Tools: Patient evaluation questionnaire, Index of Quality of Life, Psoriasis Life Stress Inventory Scale, and Psoriasis Disability Index were the four instruments employed. Results: Psoriasis disease affects severely on 66.7% of patients’ quality of life. Additionally, 63.6% of patients had severe stress related to psoriasis. Moreover, 75.8% of patients had very large effect of total disability related psoriasis disease. Conclusion: More than two-thirds of patients with psoriasis are having negative impact on total QOL. As well, about two thirds of patients had severe stress and more than three quarters of them are having very large effect of disability. Recommendations: To generalize the findings, replicate this study on a large number of psoriasis patients in various settings.