Introduction: Globally, up to one out of 100 people will experience schizophrenia. Schizophrenia is a chronic, persistent, frequently recurrent psychiatric condition that affects early brain development with a heterogeneous genetic and neurobiological history and is expressed as a mixture of psychotic symptoms such as hallucination, delusion, disorganization, and motivational and cognitive dysfunctions. A high proportion of patients experience a relapse following improvement and remission, which results in the onset of serious symptoms, including psychosocial and occupational failure. Mental state reinforcement and support are crucially beneficial to keeping the psychological well-being in a steady state during individuals’ mental recovery. Several previous studies have reported the positive correlation that exists between the level of SOC and degree of social support, particularly family support, received. Increased SOC reduces anxiety, dysfunctional thoughts, struggles with others, and psychosocial confusion, even in the face of disabilities or life difficulties. Along these lines, confirmed that patients with a mental disorder receiving insufficient support from their direct caregivers have no positive activities, which reduce their well-being and quality of life.Undoubtedly, a person suffering from schizophrenia spectrum disorders may experience high levels of stress associated with relapse of illness, the build-up of psychopathological symptoms, and the need for further hospitalization. A higher SOC, obtained social support protects people from the onset of disorders and, if they emerge, aids in accelerating the recovery of health. It is therefore important to conduct this study to investigate the relation of SOC and social support with psychological well-being among patients with schizophrenia. Aim of the study: Having a sense of coherence (SOC) and good social support is important for psychological well-being. This study aimed to investigate the nature of SOC and social support and their relationship with psychological well-being among patients with schizophrenia. Methodology: A descriptive cross-sectional research design was used to assess a convenience sample of 148 schizophrenia patients from Zagazig University Hospital. Data were collected using a questionnaire consisting of a sociodemographic datasheet, medical datasheet, SOC scale, multidimensional social support scale, and general health questionnaire (GHQ-12). Result the present study provides significant information related to SOC, social support, and psychological well-being in patients with schizophrenia. The highest percentages of SOC were found in the comprehensibility and meaningfulness categories, respectively. Regarding the multidimensional social support, the highest percentage of such reported by the study sample was received from others, then from their family. The current results revealed that a low total percentage of psychological well-being, particularly regarding positive statements, existed among participants. Also, SOC and social support showed a highly significant positive correlation with psychological well-being. Finally, the SOC scale and the perceived social support can be considered significant positive predictors of the psychological well-being of schizophrenia patients. Conclusion: The highest percentage of SOC was reported on the comprehensibility subscale, social support was mainly received from others, and low psychological well-being was found to exist particularly for the positive statements. SOC and social support were significant positive predictors of GHQ results. Recommendations The authors recommend endorsing the application of intervention programs for patients with schizophrenia that enhance SOC to improve their psychological well-being and recovery from disease. Besides, it is recommended to offer the caregivers of schizophrenic patients more educational programs about the importance of delivering social support and its impact on patient compliance with treatment and recovery from symptoms of schizophrenia. Likewise, we need to implement strategies that strengthen the social relationships of patients in psychosocial rehabilitation.