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The validity of giving adjuvant capecitabine after standard anthracycline and/or taxanes based Neo-/Adjuvant Chemotherapy in Early Triple-Negative breast cancer patients: An Egyptian prospective multicentric phase III trial
Faculty
Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Lubna Abdul -Aziz Abdul- Aziz Muhamed
Staff Zu Site
Abstract In Staff Site
Journal:
International Journal of Cancer and Biomedical Research (IJCBR) Egyptian society of cancer
Volume:
Keywords :
, validity , giving adjuvant capecitabine after standard
Abstract:
Introduction : Triple-negative breast cancer (TNBC) is considered an aggressive breast cancer subtype .despite giving standard therapies, these patients have high metastatic and relapse rates in addition to short survival .Therefore, we conducted this trial to study the validity of giving adjuvant Capecitabine , after receiving standard neoadjuvant /adjuvant chemotherapy in operable TNBC patients .The primary end point was disease-free survival (DFS) and secondary end points were overall survival (OS) and safety profile . Material and methods:The 89 eligible patients were randomly assigned into two groups ( A “Capecitabine arm” and B “observation arm”) after receiving neo-/adjuvant anthracycline and/or taxanes-containing chemotherapy . Results : 78.7% were invasive duct carcinoma (IDC), and a median age was 48 years. 50.6% were node positive patients. 79.5% received adjuvant anthracyclines and taxanes chemotherapy protocol for group A and (75.6%) for group B . (56.2%) underwent breast- conservative surgery . regarding 4-year disease free survival (DFS) ,there was statistical significant difference between both groups ( P = 0.032) and 4-y overall survival (OS) ( P = 0.050) with an acceptable toxicity profile in the Capecitabine arm. Conclusions: Our study showed statistically significant increase in DFS and OS after giving Capecitabine to standard Neo-/Adjuvant chemotherapy in early TNBC patients with acceptible toxicity of Capecitabine arm .However , a larger study with more number of patients is recommended to give more statistical powered results.
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