Cytokine profile in Egyptian children and adolescents with COVID‐19 pneumonia: A multicenter study

Faculty Medicine Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Pediatric Pulmonology [ Pediatr Pulmonol] wily Volume:
Keywords : Cytokine profile , Egyptian children , adolescents with COVID‐19    
Abstract:
Background: To date, the cytokine profile in children and adolescent with novel coronavirus disease 2019 (COVID‐19) has not been reported. Objectives: We investigated serum levels of a panel of key cytokines in children and adolescent with COVID‐19 pneumonia with a primary focus on “cytokine storm” cytokines such as interleukin (IL)‐1β, IL‐6, IL‐17, IL‐2, IL‐4, IL‐10, interferon (IFN‐γ), tumor necrosis factor (TNF)‐α, and two chemokines interferon‐inducible protein‐10 (IP‐10) and IL‐8. We also studied whether these cytokines could be potential markers for illness severity in COVID‐19 pneumonia. Methods: Ninety‐two symptomatic patients aged less than 18 years with confirmed COVID‐19 pneumonia and 100 well‐matched healthy controls were included in this multi‐center study. For all patients, the presence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in respiratory fluid specimens was detected by real‐time reverse‐transcriptase polymerase chain reaction. We measured serum concentrations of studied cytokines by using flow cytometry.
   
     
 
       

Author Related Publications

  • Yusuf Mohamed Yusuf Hasan, "Evaluation of Neopterin as a Prognostic Marker for Severity of Pneumonia in Pediatrics", Zagazig University, 2020 More
  • Yusuf Mohamed Yusuf Hasan, "The correlation between Chitinase-Like Protein YKL-40 and Childhood Asthma in Zagazig University Hospitals", Zagazig University, 2020 More
  • Yusuf Mohamed Yusuf Hasan, "Association between blood aluminum and beta-2 receptor gene methylation with childhood asthma control", sage, 2020 More
  • Yusuf Mohamed Yusuf Hasan, "Correlation Of nicotinamideadenine dinucleotide phosphate quinone oxidoreductase 1 (NQO1) gene polymorphism and bronchial asthma", Turkish Journal of Physiotherapy and Rehabilitation (Turk J Physiother Rehabil), 2021 More
  • Yusuf Mohamed Yusuf Hasan, "Salivary Surfactant Protein D as a Biomarker of Asthma Severity in Preschool Children.", Zagazig University, 2021 More

Department Related Publications

  • Nihad Ahmed Karam AbdelFattah, "Assessment of left ventricular mass index could predict metabolic syndrome in obese children", a Department of Pediatrics, Zagazig University, Zagazig b Department of Cardiology, Zagazig University, Zagazig, 2015 More
  • Osama Mahmoud Ahmed Mohamed Elkholy, "Β2 Adrenergic Receptor Gene Polymorphism Effect on Childhood Asthma Severity and Response to Treatment", Journal of Pediatric research, 2018 More
  • Osama Mahmoud Ahmed Mohamed Elkholy, "The Antioxidant Status of Coenzyme Q10 and Vitamin E in Children with Type 1 Diabetes", journal of de pediatria, 2017 More
  • Ehab Abdelhamied Abdelsalam, "Metabolic cataract in an 8-year-old diabetic boy", The Turkish Journal of Pediatrics, 2012 More
  • Doaa mohamed abdelrahman abdel atty, "Bacterial nosocomial infections in neonatal intensive care unit, Zagazig University Hospital, Egypt", Egyptian Pediatric Association Gazette (2014) 62, 72–79, 2014 More
Tweet