Novel Benzyloxyphenyl Pyrimidine-5-Carbonitrile Derivatives as Potential Apoptotic Antiproliferative Agents

Faculty Pharmacy Year: 2022
Type of Publication: ZU Hosted Pages: 978-990
Authors:
Amany Mohamed Mohamed Elmahmoudy Sanger
Journal: Anti-Cancer Agents in Medicinal Chemistry Bentham Science Publishers Volume:
Keywords : Novel Benzyloxyphenyl Pyrimidine-5-Carbonitrile Derivatives , Potential Apoptotic    
Abstract:
Abstract: Background: Pyrimidine-5-carbonitrile has a broad spectrum of biological activities such as antiviral, antioxidant, and anticancer activities. Among similar compounds, monastrol is the most prominent cell-permeant inhibitor of mitosis; therefore, we investigated the new Pyrimidine-5-carbonitrile as a cytotoxic agent for the p53 pathway. Objective: Several new benzyloxyphenyl pyrimidine-5-carbonitrile derivatives were designed, synthesized, and characterized, and their cytotoxicity was evaluated. The most active compounds were tested for their activity against p53 as a mechanistic target for antiproliferative action.
    
     
 
       

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