Background& Aim: Several treatment forms have been utilized to remove the pain following laparoscopic cholecystectomy (LC), including nonsteroidal anti-inflammatory drugs, opioids and local anaesthetics, however none has elucidated harmonious effectiveness. So, this study aimed to estimate the effectiveness of intraperitoneal (IP) lidocaine with tenoxicam on relieving the pain and bowel recovery post LC. Methods: A prospective clinical trial was performed in the General Surgery department, Zagazig University Hospitals, Egypt, between March 2019-March 2020. Such study was done on 126 patients suffered from chronic calcular cholecystitis categorized into two groups: Group (A): patients underwent LC without IP lidocaine or tenoxicam and Group (B): patients underwent LC with IP lidocaine and tenoxicam. Results: There was no significant variations among both groups concerning demographic and clinical characteristics. Furthermore, there was no significant variations concerning operation time or anesthesia time. Pain control satisfaction score (PCSS) was significantly higher in Group B. Visual analogue scale (VAS) was significantly lower at Group B from two-six hours with no significant variation at eight & 12 hours at rest or movement. The time of 1st demanded analgesia was earlier in Group A and total analgesia dosage was significantly higher between Group A. Group B was significantly shorter concerning bowel sound/h, oral intake/h, ambulation/h, and hospital stay/day. The shoulder pain and nausea were significantly correlating with Group A and also vomit was higher in Group A but not statistically significant. Conclusions: IP lidocaine with tenoxicam administration is a viable alternative when seeking to alleviate postoperative pain among patients undergoing LC