Purpose: To report the outcomes of using topical mitomycin-C (MMC) after reconstructive surgery for ‎contracted socket and to compare the results with those of the conventional postoperative treatment. ‎ Patients and Methods: The medical records of patients who underwent reconstructive surgery for ‎contracted anophthalmic socket were retrospectively reviewed. Based on the postoperative treatment ‎protocol, two groups of patients were identified; group I (15 patients) who received topical MMC drops ‎‎(0.02%) 4 times daily for 6 weeks and group II (15 patients) who received the conventional treatment ‎‎(topical antibiotic-steroid combination). Preoperative data were extracted for age, gender, cause and ‎timing of anophthalmia, history of previous surgeries, preoperative forniceal depth and socket volume ‎‎(SV). The main postoperative outcome measures were superior fornix depth (SFD), inferior fornix depth ‎‎(IFD) and SV at the end of 6th postoperative month. Prosthesis fitting and complications were also ‎considered for analysis. ‎ Results: The mean preoperative IFD was 1.67±0.04 mm in group I and 1.58±0.37 mm in group II, by the ‎end of the 6th postoperative month it increased to 6.1 ±0.27 mm and 5.12 ±0.25mm, respectively. The ‎mean preoperative SFD in group I was 8.3±0.9 mm and 8.9 ±1.1 mm in group II, by the end of the 6th ‎postoperative month SFD became 13.4±1.2 mm and 10.2±1.4 mm in groups I and II, respectively. The ‎mean SV measured six months postoperatively was 1.9±0.2 mL and 1.3±0.09 mL in groups I and II, ‎respectively. These differences in the postoperative SFD, IFD and SV between both groups were ‎statistically significant. More cases reported successful fitting in group I than in group II but this ‎difference was not statistically significant. ‎ Conclusion: Postoperative use of topical MMC is associated with higher forniceal depth and greater SV ‎when compared to the conventional treatment in socket reconstructive surgeries with amniotic ‎membrane graft (AMG‎