Background: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in Egypt. HCCs usually have a poor prognosis due to late diagnosis, aggressive metastasis and early invasion. Heterogeneous ribonucleoproteins (HnRNPs) are nuclear proteins that play a variety of roles in telomere formation, DNA repair, cell signaling, and gene regulation. Zinc finger E box binding homeobox (ZEB) are transcription factors that have a consistent inverse correlation with E cadherin in numerous types of cancer and associated with poor prognosis. Aim: Study aimed to verify the prognostic expression of HnRNP A1, ZEB1 and E-cadherin in HCC. Settings and Design: Retrospective study consisted of 54 formalin fixed paraffin embedded tissue blocks of hepatocellular carcinoma Methods and Material: Immunohistochemical staining was done using antibodies against HnRNP A1, ZEB1 and E-cadherin. The patients were followed at Clinical Oncology Department from May 2018 to July 2021. Statistical analysis: SPSS version 20 using Chi square test to compare data and Kaplan Meier plot for comparing survival. Results: HnRNP A1 high positivity was detected in 59.3% of cases, whereas negative E-cadherin and ZEB 1 expression presented in 37 % and 70.4% of patients respectively. A statistically significant relation was present between HnRNP A1, ZEB1, E-cadherin and various clinicopathological variables. The mean PFS and OS in low HnRNP A1 and negative ZEB1 expressions were longer than those exhibited high HnRNP A1 and positive ZEB1expressions. Conclusion: HnRNP A1 and ZEB1 expressions are poor prognostic factors of HCC. E-cadherin has an important role in the development of differentiated HCCs and favorable outcome.