Initial lymphocyte to monocyte ratio as a surrogate marker of survival in adults with de novo non-M3 acute myeloid leukemia:

Faculty Medicine Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Shehata Mostafa Embaby
Journal: Hematology Reports Hematology Reports Volume:
Keywords : Initial lymphocyte , monocyte ratio , , surrogate marker    
Abstract:
Introduction: Low absolute lymphocyte/monocyte ratio (LMR) at presentation has been associated with clinical outcome in various types of hematological malignancies including multiple myeloma, Hodgkin's and non-Hodgkin's lymphomas, but to the best of our knowledge, no data are available on its role in acute myeloid leukemia (AML). This study aims to investigate the prognostic significance of LMR at diagnosis, as a simple biomarker merging an index of host immune homeostasis with tumor microenvironment, in de novo AML. Methods: In this prospective cohort study, we evaluated 100 previously untreated adult patients with de novo non-M3 AML, aged 18 years or older and treated at Clinical Hematology Unit, Internal Medicine department at Zagazig University Hospitals, from September 2016 to August 2019. The estimated initial LMR cut-off value for survival outcome generated by receiver operating …
    
     
 
       

Author Related Publications

  • Ahmed Shehata Mostafa Embaby, "Impact of Immunochemotherapy-Related Hepatic Toxicity on the Outcome of HCV-Positive Diffuse Large B-Cell Lymphoma Patients", Hindawi Publishing Corporation, 2014 More
  • Ahmed Shehata Mostafa Embaby, "Prognostic significance of lymphocyte-to-monocyte ratio in patients with classical Hodgkin lymphoma before and after receiving first-line chemotherapy", Termedia Publishing House Ltd, 2022 More
  • Ahmed Shehata Mostafa Embaby, "Initial absolute monocyte count as an immune biomarker for clinical response in acute myeloid leukemia with monocytic differentiation", springer one, 2020 More
  • Ahmed Shehata Mostafa Embaby, "Use of prophylactic closed-incision negative-pressure therapy (CINPT) is associated with reduced surgical-site infections in patients undergoing open abdominal surgeries during the Covid-19 pandemic", Medknow, 2021 More
  • Ahmed Shehata Mostafa Embaby, "Predictive Factors of Para-Aortic Lymph Nodes Metastasis and Survival Advantages of Para-Aortic Lymphadenectomy in Early Stage Cervical Cancer", Mary Ann Liebert, Inc., publishers, 2021 More

Department Related Publications

  • Mohammed Sallam Suleiman Saad, "Role of MicroRNA 126 in Screening, Diagnosis, and Prognosis of Diabetic Patients in Egypt", wiley, 2016 More
  • Mohamed Essam El Din Ahmd, "Effect of aerobic exercises on blood coagulation and fibrinolytic system in type 2 diabetic patients", International Journal of Advanced research (2015), Volume 3, Issue 5,64-70, 2015 More
  • Nafisa Mohamed KamalElDin, "Prevalence and effect of SEN virus in hemodialysis patients in Zagazig university nephrology unit", on line, 2016 More
  • Huda Abdul Aziz Hadi Ahmad, "Evaluation of Some Non Invasive Predictors for Presence of Esophageal Varices in Patients with Compensated HCV Positive Cirrhosis", International Journal of Science and Research (IJSR), 2016 More
  • Fady Maher Wadie Abdo, "Evaluation of Thyroid Dysfunction in Egyptian Chronic Hepatitis C Virus Cirrhotic Patients Complicated with Portal Hypertension", International Journal of Science and Research, 2016 More
Tweet