Abstract Background and study aim: : Helminthic and protozoal infestation of the alimentary tract is endemic in tropical and subtropical areas and also occur in temperate zones. The aim of this study was to evaluate the frequency and characterization of parasites detected during upper digestive endoscopic procedures. Patients and methods:: Retrospective analysis of the records of patients exposed to upper endoscopic procedures in the endoscopy units, Tropical Medicine Department, Zagazig University Hospitals, Egypt in a 5 year period extending from January 2007 to January 2012. A total of 4925 cases were included; 4708 cases for gastrodudenoscopy (EGDS) and 217 cases for endoscopic-retrograde-cholangio-pancreatography (ERCP). All cases were reviewed as regard age, sex, residence, indications for endoscopy and endoscopic features. Cases with parasitic infestations were characterized regarding the mentioned variables. Results : :A total of 8 cases with parasitic infestations were described. Six cases detected by EGDS and 2 cases by ERCP. Five cases were Ancylostoma duodenale , one case Ascaris lumbricoides, one case Strongyloides stercoralis and one case Fasciola hepatica. Most cases were presented with anemia and persistent epigastric pain. Seven cases were associated with duodenitis on endoscopic examination. Conclusion : :Parasites are not common findings during upper digestive endoscopic procedures, and should be suspected in patients with anemia and persistent epigastric pain.