Background: Worldwide, breast cancer is the most prevalence cancer in women. The prevalence of breast cancer about 29% of new cases of cancer and about 14% of cancer deaths in women, secondly to lung cancer as a cause of cancer-death, Aim and objectives: The aim of the current study was to study the outcomes of treatment of locally advanced breast cancer in Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals. Subjects and methods: This retrospective cohort study was carried in Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals, the included All old locally advanced breast cancer patients files in Clinical Oncology and Nuclear Medicine Department medical records of (2012 - 2013). Results: There was a significant statistical difference between group with distant metastasis and group with no distant metastasis regarding N system and stage of the tumor while there was no significant statistical difference regarding other parameters and there was no significant statistical difference between group with distant metastasis and group with no distant metastasis regarding radiotherapy. Conclusion: LABC in Egypt showed poor prognostic outcome and advanced management of locally advanced breast cancer required for improving chemotherapy regimens, predictors of chemotherapy response and imaging techniques