Introduction :Neoadjuvant chemo-radiotherapy has the advantages of decrease local recurrence rate , deceasing toxicity , down_staging the tumor and minimize rate of mobidity . Methods: Patients were divided into 2 groups in accordance type of preoperative Therapy ,Group 1: included 30 patients comprised those who had colorectal carcinoma with laparoscopic intervention without neoadjuvant therapy,Group 2: included 30 patients comprised those who had colorectal carcinoma with laparoscopic intervention with neoadjuvant therapy, This study included patients with colorectal carcinoma were admitted to Zagazig University Hospital & Gastrointestinal surgery center ( Mansoura university). Cases were collected in the period from December 2016 to April 2018. The study was approved by the research and Ethics committee of Zagazig University & Mansoura university. a written informed consent was obtained from all participating patients after explaining to them all the study procedures with its benefits and hazards.the work has been carried out in accordance with the code of ethics of the world medical association ( Declaration of Helsinki ) for studies involving humans. Results: the results showed that there are significant differences between laparoscopic colectomy with neoadjuvant chemo-radiotheropy and those without neoadjuvant therapy in cases of rectal carcinoma while in cases of colon cancer there are no significant differences . laparoscopic colectomy has more advantages than open surgery in early ambulation , decrease time in staying in hospital , early return to work . Conclusion: Laparoscopic colorectal resection after neoadjuvant chemo-radiotherapy has higher conversion rate & longer duration of surgery.Mortality & morbidity are equal in both groups