Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation

Faculty Pharmacy Year: 2015
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Ezat Mahmoud Mohamed El Zowalaty
Journal: Biology of reproduction Oxford University Press Volume:
Keywords : Deletion , Lysophosphatidic Acid Receptor , (Lpar3) Disrupts    
Abstract:
Deletion of Lpar3 (the third G protein-coupled receptor for lysophosphatidic acid (LPA) leads to an increased ratio of progesterone signaling/estrogen signaling that can be optimized by low doses of RU486 or E2 to restore on-time implantation in knockout females.
    
     
 
       

Author Related Publications

  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Timing and recovery of postweaning exposure to diethylstilbestrol on early pregnancy in CD-1 mice", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2−/− female mice with lipodystrophy", Elsevier, 2014 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Olfactomedin 1 Deficiency Leads to Defective Olfaction and Impaired Female Fertility", Oxford University Press, 2015 More
  • Ahmed Ezat Mahmoud Mohamed El Zowalaty, "Identification of potential SARS-CoV-2 main protease and spike protein inhibitors from the genus aloe: An in silico study for drug development", Multidisciplinary Digital Publishing Institute, 2021 More

Department Related Publications

  • Samar Abdelmigeed Mohamed Rezk, "Central GPR109A Activation Mediates Glutamate-Dependent Pressor Response in Conscious Rats.", USA, 2016 More
  • Mona Fouad Mahmoud Abdelaziz, "Curcumin and hemopressin treatment attenuates cholestasis-induced liver fibrosis in rats: role of CB1 receptors", Naunyn-Schmiedeberg's archives of pharmacology, 2016 More
  • Mona Fouad Mahmoud Abdelaziz, "Role of cannabinoid receptors in hepatic fibrosis and apoptosis associated with bile duct ligation in rats", Elsevier, 2014 More
  • Mona Fouad Mahmoud Abdelaziz, "Leonotis ocymifolia (Burm. f.) Iwarsson aerial parts aqueous extract mitigates cisplatin-induced nephrotoxicity via attenuation of inflammation, and DNA damage", Frontiers, 2023 More
  • Mona Fouad Mahmoud Abdelaziz, "Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L.(Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments", Frontiers Media SA, 2023 More
Tweet