The protective role of selenium nanoparticles in sodium fluoride induced thyroid disorders in adult rats : a histological and immunochistochemical study

Faculty Medicine Year: 2018
Type of Publication: ZU Hosted Pages:
Authors:
Journal: British journal of science ISSN 2047-3745 Volume:
Keywords : , protective role , selenium nanoparticles , sodium fluoride    
Abstract:
Introduction: The thyroid gland plays an important role in human health. Fluoride disturbs the synthesis and secretion of thyroid hormones. Selenium at nano size (Nano- Se) has an equal efficacy like selenium as an antioxidant but with reduced risk of its toxicity. Aim of the work: This study was done to evaluate the effect of sodium fluoride on the structure and function of the thyroid gland and to throw more light on the role of selenium nanoparticles (Se-NPs) as a new line of therapy. Information about recovery of thyroid gland after stoppage of sodium fluoride was also investigated. Material and Methods: Forty eight adult male albino rats were divided into four equal groups; control group, fluoride-treated group, fluoride and SeNPs treated group and fluoride recovery group. At the end of the experimental period, blood samples were collected for serological study (T3, T4 and TSH) and thyroid specimens were processed for light and electron microscope examination. Results: Histological examination of thyroid gland showed marked structural changes with decreased level of thyroid hormones in fluoride treated group. These changes were slightly decreased in fluoride recovery group while improved in fluoride and SeNPs treated group. Conclusion: Se nanoparticles can improve the adverse effects of sodium fluoride on the thyroid gland. The antioxidant activity of Nano-Se may be a major reason for its positive impact on the thyroid fluorosis. On the other hand, fluoride induced thyroid damage could be partially reversed by stoppage of sodium fluoride treatment. Recommendation: Selenium nanoparticles could be considered to be experimentally effective in case of thyroid fluorosis. The therapeutic benefits of Se-NPs will make them the first drug of choice in the future.
   
     
 
       

Author Related Publications

  • Zinab Mansour Mohamed Salem, "The Possible Protective Effect of Ocimum Basilicum L. Aqueous Extract on Aspirin Induced Damage of Gastric Mucosa in Adult Male Albino Rats: Histological and Ultrastructural Study", ISSN:2536-9172, 2019 More
  • Zinab Mansour Mohamed Salem, "The Possible Effects of Caffeine and Nicotine on the Pathogenesis of Experimentally Induced Alcoholic Pancreatitis: A Histological and Immunohistochemical Study", ISSN:2536-9172, 2020 More
  • Zinab Mansour Mohamed Salem, "the effet of fluoxetine on the strucure of adult rat parotid glands and the possible role of pilocarpine with nizatidine: a histological and immunohistochemical study", egyptian journal of histology, 2013 More
  • Zinab Mansour Mohamed Salem, "efect of cyclosporine A on the structure of adult albino rat testis and the role of lycopene supplemntation : a histological and immunohistochemical study", egyptian journal of histology, 2014 More
  • Zinab Mansour Mohamed Salem, "effect of monosodium glutamate on the fallopian tubes of adult albino rats and the possible protective role of vitamin c: histological and immunohistochemical study", egyptian journal of histology, 2015 More

Department Related Publications

  • Nihad Fahmy Ahmed Ibrahim, "دراسة هستولوجية و بيوكيميائية عن الدور الوقائى للوسارتان على قشرة كلى الجرذان فى حالات القصور الكبدى المحدث تجريبيا", The Egyptian Journal of Histology, June 2013, 36(2): 365-378, 2013 More
  • Manal Reda Abdel Elhaleem Omar, "Pomegranate protective effect on experimental ischemia/reperfusion retinal injury in rats (histological and biochemical study)", Taylor & Francis, 2017 More
  • Mona Gomaa Mohammed Mohammed Amir, "Pomegranate protective effect on experimental ischemia/reperfusion retinal injury in rats (histological and biochemical study)", Taylor & Francis, 2017 More
  • Halle Alawi Hashim, "Pomegranate protective effect on experimental ischemia/reperfusion retinal injury in rats (histological and biochemical study)", Taylor & Francis, 2017 More
  • Manal Reda Abdel Elhaleem Omar, "Pomegranate protective effect on experimental ischemia/reperfusion retinal injury in rats (histological and biochemical study)", Taylor & Francis, 2017 More
Tweet