Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Association between HindIII (rs320) variant in the lipoprotein lipase gene and the presence of coronary artery disease and stroke among the Saudi population
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Reem Mohamed ElSayed Mohamed Allam
Staff Zu Site
Abstract In Staff Site
Journal:
Saudi Journal of Biological Sciences Elsevier B.V
Volume:
Keywords :
Association between HindIII (rs320) variant , , lipoprotein
Abstract:
Lipoprotein Lipase (LPL) is known to be a key enzyme for lipid metabolism specifically in an enzymatic glycoprotein which provide tissues without fatty-acids and eliminates triglycerides (TG) by the circulation. Mutations in LPL were proven to cause alteration in fractions within lipoprotein, causing the development of atherosclerosis which predispose to weakening coronary artery disease (CAD) and stroke. We examined the linkage between genetic variant HindIII in LPL on lipoprotein fractions, stroke occurrences and CAD. In this case-control study, we have recruited 315 CAD cases and 205 age-matched controls. A total of 520 genomic DNA was digested with the purified PCR products for restriction fragment length polymorphism with HindIII restriction enzyme. The distribution of genotypes in a decreasing order were TT, 148 (47%), GT 135 (42.9%) and GG 32 (10.2%) in CAD groups of the study while the pattern in controls were GT 91 (44.4%), TT 86 (42%) and GG 28 (13.7%). None of all the allele or genotype frequencies were found to be significant in our study (p greater than 0.05), while the biochemical levels for both TG and LDL-c were shown to be prone in CAD patients when compare with the controls. Furthermore, the occurence of strokes were more in CAD groups vs. controls: 72 (22.9%) vs. 7 (3.4%) [p 0.000]. This could indicate the influence of HindIII variant on plasma lipid levels, and the possibility of considering it a risk factor for atherosclerosis leading to CAD and stroke occurrence
Author Related Publications
Reem Mohamed ElSayed Mohamed Allam, "Association between UGT-1A1 gene GLY71Arg polymorphism and severe unexplained indirect hyperbilirubinemia among neonates", Wolters Kluwer - Medknow, 2018
More
Reem Mohamed ElSayed Mohamed Allam, "The expression level of microRNA-122 in patients with type 2 diabetes mellitus in correlation with risk and severity of coronary artery disease", Wolters Kluwer - Medknow, 2019
More
Reem Mohamed ElSayed Mohamed Allam, "Maternal vitamin D level and vitamin D receptor gene polymorphism as a risk factor for congenital heart diseases in offspring; An Egyptian case-control study", Elsevier B.V, 2018
More
Reem Mohamed ElSayed Mohamed Allam, "Influence of +299G>A and +62G˃A resistin gene promoter variants on cardiovascular risk in Egyptian women with systemic lupus erythematosus", Elsevier B.V, 2018
More
Reem Mohamed ElSayed Mohamed Allam, "Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population", Dove Medical Press Limited, 2021
More
Department Related Publications
Hoda fathy mohamed, "The usefulness of immunoglobulin-like transcript-3 receptor expression in the diagnosis of acute myeloid leukemia with monocytic differentiation", The Egyptian Society of Haematology, 2014
More
Hoda fathy mohamed, "CD200 Suppresses the Natural Killer Cells and Decreased its Activity in Acute Myeloid Leukemia Patients", ISSN:2329-6917 JLU, an open access journal, 2014
More
Ahmed Abdelsabour Mohamed Moussa, "Late onset neonatal sepsis: Can plasma gelsolin be a promising diagnostic marker?", LWW, 2024
More
Ahmed Abdelsabour Mohamed Moussa, "Impact of Prognostic Nutritional Index and Systemic Immune-Inflammation Index on the Clinical Outcome of Diffuse Large B Cell Lymphoma Patients Treated with RCHOP", Zagazig University, Faculty of Medicine, 2024
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف