Background: Epistaxis, or nosebleeds, is a common complaint especially in young children. Most of the risk factors causing epistaxis are preventable or modifiable, so identification of these risk factors decreases complications that may occur with the disease. Objectives: To determine the related risk factors of epistaxis and its frequency among children aged 6-12 in Lower Egypt. Methods: a cross-sectional study was conducted on 758 children. Using multistage sampling technique, Sharkia and Menoufia governorates were selected to represent Lower Egypt, Zagazig and Shebin El-Kom health districts were selected, then four family health facilities were chosen to represent urban and rural areas. Data on participants’ socio-demographic characteristics, characteristics of epistaxis attacks and many related risk factors were collected via a semi-structured questionnaire. Results: The study revealed a high frequency of epistaxis (35.4%) among children aged 6-12. About (53.3%) of them were of low socioeconomic standard. The attacks were more frequent in winter (43.7%), and most of them were of a little amount of bleeding. the risk was more evident with head and face trauma, exposure to cigarette smoke, children suffering from chronic coughing or nasal allergy, or using steroid-containing drugs. Conclusion: There is a high frequency of epistaxis among young children. Most of the related risk factors are easily modifiable to prevent the recurrence of the attacks. Health education related to children's safety measures along with fostering awareness about epistaxis red flags is still needed.