Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Serum levels of leptin and adiponectin in patients with multiple sclerosis
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Rasha Mohamed Fahmy Abdelhaliem
Staff Zu Site
Abstract In Staff Site
Journal:
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Springer Nature
Volume:
Keywords :
Serum levels , leptin , adiponectin in patients with
Abstract:
Background: The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. The aim of this study is to demonstrate the serum levels of leptin and adiponectin in MS patients and to assess their association with disease disability and severity. A case–control study including 60 subjects (30 MS patients and 30 age, sex and body mass index-matched healthy controls) was performed. Results: Serum leptin level was significantly higher among MS patients than controls (P < 0.001) while adiponectin was not significantly elevated in MS patients (P = 0.24). There was a significant positive correlation between leptin levels with MS disability (Expanded Disability Status Scale) (r = 0.678; P < 0.001), severity (Multiple Sclerosis Severity Score) (r = 0.631; P < 0.001) and progression (progression index) (r = 0.461; P = 0.01). There was no statistically significant correlation between adiponectin with disease disability, severity or progression. Conclusions: MS patients had significantly higher serum leptin levels and insignificant adiponectin levels compared to controls. Leptin has a potential role in multiple sclerosis disability and severity. However, adiponectin is not useful as a biomarker of MS disease, disability and severity. Keywords: Multiple Sclerosis, Leptin, Adiponectin, Disability, EDSS, MSSS
Author Related Publications
Rasha Mohamed Fahmy Abdelhaliem, "Vitamin D Levels in Patients with Multiple Sclerosis", [Egypt J Neurol Psychiat Neurosurg. 2014; 51(2): 145-152], 2014
More
Rasha Mohamed Fahmy Abdelhaliem, "COMPARATIVE EVALUATION OF SOME ANTIEPILEPTIC DRUGS ON LIPID PROFILE AND CAROTID INTIMA THICKNESS IN A SAMPLE OF EGYPTIAN CHILDREN: A ONE YEAR PROSPECTIVE STUDY.", International Journal of Advanced Research (2016), Volume 4, Issue 6, 178-185, 2016
More
Rasha Mohamed Fahmy Abdelhaliem, "Renal Dysfunction and White Matter Hyperintensity in Patients with Ischemic Stroke", [Egypt J Neurol Psychiat Neurosurg. 2014; 51(1): 105-111, 2014
More
Rasha Mohamed Fahmy Abdelhaliem, "Improving Cognitive Impairment of Elderly by an Educational Program for Their Caregivers", American Journal of Nursing Science, 2015
More
Rasha Mohamed Fahmy Abdelhaliem, "Association of Plasma Epidermal Growth Factor with Cognitive Function in Parkinson Disease Patients", [Egypt J Neurol Psychiat Neurosurg, 2015
More
Department Related Publications
Rasha Mohamed Fahmy Abdelhaliem, "Renal Dysfunction and White Matter Hyperintensity in Patients with Ischemic Stroke", [Egypt J Neurol Psychiat Neurosurg. 2014; 51(1): 105-111, 2014
More
Rasha Mohamed Fahmy Abdelhaliem, "Frequency and determinants of subclinical neuropathy in type 1 Diabetes mellitus", Egypt J Neurol Psychiat Neurosurg., 2016
More
Hanan Mohamed Sabry Nasr, "Interleukin-6 and hs-CRP as Early Diagnostic Biomarkers for Obesity-Related Peripheral Polyneuropathy in Non-Diabetic Patients", THE EGYPTIAN JOURNAL OF IMMUNOLOGY, 2018
More
Mona Mohammed Amer Mohamd, "Endothelial-Specific Molecule 1 (Endocan) As A Marker of Vascular Endothelial Regulation of Obesity-Associated Peripheral Polyneuropathy in The Non-Diabetic Obese Patients.", المجلة العلمية لجامعة القاهرة, 2019
More
Halle Ahmed Fathy Hafez, "Interleukin-6 and hs CRP as early diagnostic biomarkers for obesity related peripheral polyneuropathy in non-diabetic patients.", THE EGYPTIAN JOURNAL OF IMMUNOLOGY Vol. 25 (2), 2018, 2018
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف