Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues

Faculty Pharmacy Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Hend Kather Abdelhakem Elhamalawy
Journal: BMC Chemistry springer nature Volume:
Keywords : Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole    
Abstract:
Two series of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues were designed and synthesised as novel antimicrobial drugs through inhibition of phenylalanyl-tRNA synthetase (PheRS), which is a promising antimicrobial target. Compounds were designed to mimic the structural features of phenylalanyl adenylate (Phe-AMP) the PheRS natural substrate.
    
     
 
       

Author Related Publications

  • Hend Kather Abdelhakem Elhamalawy, "Preclinical evaluation of Rad6 inhibition to overcome platinum resistance in ovarian cancer", AACR, 2016 More
  • Hend Kather Abdelhakem Elhamalawy, "Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides", ELSEVIER, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of New 2,3-Dihydroquinazolin-4(1H)-one Derivatives for Analgesic and Anti-inflammatory Evaluation", WILEY interscience, 2010 More
  • Hend Kather Abdelhakem Elhamalawy, "Synthesis of new benzotriazepin-5(2H)-one derivatives of expected antipsychotic activity", springer link, 2013 More
  • Hend Kather Abdelhakem Elhamalawy, "Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization", AACR publications, 2013 More

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  • Mansour Alsayed Mansour Abokol, "SPECTROPHOTOMETRIC DETERMINATION OF KETOPROFEN IN PHARMACEUTICAL PREPARATIONS BY MEANS OF CHARGE TRANSFER COMPLEXES", Talnta. Vol. 40. No. 4 pp. 585-588, 1993 More
  • Mansour Alsayed Mansour Abokol, "REACTION OF 2, 3- DICHLOROMALEIC ANHYDRIDE I: NITROSATIVE REDUCTIVE ELIMINATION; SYNTHESIS OF N-(2,6-DIMETHYLPHENYL)-2-(N-NITROSO-N-SUBSTITUTED)AMINO- SUCCINIMIDES", Chim. Farmaceutico – Anno 135 –pp.429-433 n. 7 Luglio/Agosto, 1996 More
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