Design, computational studies, synthesis
and in vitro antimicrobial evaluation
of benzimidazole based thio-oxadiazole
and thio-thiadiazole analogues

Faculty	Pharmacy	Year:	2021
Type of Publication:	ZU Hosted	Pages:
Authors:	Hend Kather Abdelhakem Elhamalawy Staff Zu Site Abstract In Staff Site
Journal:	BMC Chemistry springer nature	Volume:

Keywords :	Design, computational studies, synthesis and in vitro antimicrobial evaluation of benzimidazole
Abstract:	Two series of benzimidazole based thio-oxadiazole and thio-thiadiazole analogues were designed and synthesised as novel antimicrobial drugs through inhibition of phenylalanyl-tRNA synthetase (PheRS), which is a promising antimicrobial target. Compounds were designed to mimic the structural features of phenylalanyl adenylate (Phe-AMP) the PheRS natural substrate.

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