In this work, we introduce an integration matrix operator that is fully consistent with the differentiation matrix operator defined by the differential quadrature method (DQM). Using these operators, a generic differential-integral quadrature method “DIQM” is proposed to directly discretize an integro-differential equation as a system of algebraic equations. To extend the applicability of the proposed DIQM to solve nonlinear and/or variable coefficients integrodifferential equation, some matrix manipulations are introduced. A stability analysis for Volterra integro-partial-differential equations is presented and the exponential convergence of the proposed method is examined. Various types of integro-differential equations are solved including ordinary/partial, linear/ nonlinear, Volterra parabolic/hyperbolic integro-differential equations with different boundary and initial conditions. Numerical results demonstrate the exponential convergence and the applicability of DIQM.